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ResearchThe mitochondrial metabolic function of DJ-1 is modulated by 14-3-3βMaria Weinert, Aurelie Millet, Elizabeth A. Jonas, and Kambiz N. AlavianMaria Weinert*Division of Brain Sciences, Department of Medicine, Imperial College London, London, United Kingdom; Search for more papers by this autho... ... See more

https://www.imperial.ac.uk/news/190525/parkinsons-treatment-delivers-power-up-brain-cell/

Scientists have gained clues into how a Parkinson’s disease treatment, called deep brain stimulation, helps tackle symptoms.

ResearchPost mortem examination of Parkinson’s disease brains suggests decline in mitochondrial biomass, reversed by deep brain stimulation of subthalamic nucleusAnna Mallach, Maria Weinert, Joy Arthur, Djordje Gveric, Travis S. Tierney, and Kambiz N. AlavianAnna Mallach*Division of Brain Sciences... ... See more

ATP synthase is a complex universal enzyme responsible for ATP synthesis across all kingdoms of life. The F-type ATP synthase has been suggested to have evolved from two functionally independent, cata

Cell death and differentiation is a monthly research journal focused on the exciting field of programmed cell death and apoptosis. It provides a single accessible source of information for both scientists and clinicians, keeping them up-to-date with advances in the field. It encompasses programmed c... ... See more

Direct and indirect functional links between proteins as well as their interactions as part of larger protein complexes or common signaling pathways may be predicted by analyzing the correlation of their evolutionary patterns. Based on phylogenetic profiling, here we present a highly scalable and ti... ... See more

Activity of the protein kinase SGK1 is reduced in the prefrontal cortex of individuals with post-traumatic stress disorder (PTSD), and SGK1 inhibition can cause PTSD-related behavioral changes in an animal model. ... See more

Reduced activity of a brain protein linked to post-traumatic stress disorder

People with post-traumatic stress disorder (PTSD) have reduced activity of the protein serum and glucocorticoid regulated kinase 1 (SGK1) in their prefrontal cortices, and experimentally reducing the protein's activity in rats leads to PTSD-like behavior, according to a new study in PLOS Biology.

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http://sciencemission.com/site/index.php?page=news&type=view&id=neuroscience-psychology%2Freduced-activity-of-a&filter=8%2C9%2C10%2C11%2C12%2C13%2C14%2C16%2C17%2C18%2C19%2C20%2C27 ... See more

Jonas, E. A., Porter, G. A., Beutner, G., Mnatsakanyan, N. and Alavian, K. N. (2015) The Mitochondrial Permeability Transition Pore, the c-Subunit of the F1Fo ATP Synthase, Cellular Development, and Synaptic Efficiency, in The Functions, Disease-Related Dysfunctions, and Therapeutic Targeting of Neu… ... See more

http://www.sciencedirect.com/science/article/pii/S104366181500081X

Ion transport across the mitochondrial inner and outer membranes is central to mitochondrial function, including regulation of oxidative phosphorylation and cell death. Although essential for ATP production by mitochondria, recent findings have confirmed that the c-subunit of the ATP synthase also h… ... See more