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Enterprise at Imperial College London@ImperialIdeas·17 Aug
Powering down the mitochondria in #braincancer cells may be the key to new treatments. @ImperialCollege startup GlioQuell is applying #drugdiscovery knowhow from the @Kambiz_Alavian lab to bring this innovation to patients. https://hubs.ly/Q01kcVvF0 @ImperialBrains
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Imperial College London@imperialcollege·17 Aug
Powering down the mitochondria - the energy-producing structure of a cell - in brain cancer cells could be the key to new treatments.



Startup GlioQuell is applying knowhow from the @Kambiz_Alavian lab to accelerate the development of new treatments.

⬇️

http://ow.ly/6qzh50KlFob
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Mathew Piasecki@MathewPiasecki·15 Jun
At The Exchange in Birmingham for the first of the MyAge sandpit events, supported by @BBSRC and @The_MRC .

Aim is to build collaborations involving early career researchers, with pump priming funds available 

@UkAgeing @KeithMGodfrey https://www.ukanet.org.uk/my-age/ 
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Mathew Piasecki@MathewPiasecki·24 May
Launch of the MyAge Ageing Network: 



MUSCLE RESILIENCE ACROSS THE LIFE COURSE: FROM CELLS TO SOCIETY

What is the future of ageing research?

https://www.ukanet.org.uk/my-age/



@UkAgeing @BBSRC @The_MRC @KeithMGodfrey 
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Alavian Lab@AlavianLab·12 May
Imperial research is best in UK, finds REF 2021 | Imperial News | Imperial College London https://www.imperial.ac.uk/news/236379/imperial-research-best-uk-finds-ref/
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3 years ago

The mitochondrial metabolic function of DJ-1 is modulated by 14-3-3β | The FASEB Journal

ResearchThe mitochondrial metabolic function of DJ-1 is modulated by 14-3-3βMaria Weinert, Aurelie Millet, Elizabeth A. Jonas, and Kambiz N. AlavianMaria Weinert*Division of Brain Sciences, ... See more

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3 years ago

Parkinson’s treatment delivers a power-up to brain cell ‘batteries' | Imperial News | Imperial College London

https://www.imperial.ac.uk/news/190525/parkinsons-treatment-delivers-power-up-brain-cell/

Scientists have gained clues into how a Parkinson’s disease treatment, called deep brain stimulation, helps tackle symptoms.

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3 years ago

Post mortem examination of Parkinson’s disease brains suggests decline in mitochondrial biomass, reversed by deep brain stimulation of subthalamic nucleus | The FASEB Journal

ResearchPost mortem examination of Parkinson’s disease brains suggests decline in mitochondrial biomass, reversed by deep brain stimulation of subthalamic nucleusAnna Mallach, Maria Weinert, Joy ... See more

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5 years ago

Phylogenetic Profiling of Mitochondrial Proteins and Integration Analysis of Bacterial Transcription Units Suggest Evolution of F1Fo ATP Synthase from Multiple Modules

ATP synthase is a complex universal enzyme responsible for ATP synthesis across all kingdoms of life. The F-type ATP synthase has been suggested to have evolved from two functionally independent, cata

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5 years ago

Cell Death and Differentiation - Inhibition of Bcl-xL prevents pro-death actions of [Delta]N-Bcl-xL at the mitochondrial inner membrane during glutamate excitotoxicity

Cell death and differentiation is a monthly research journal focused on the exciting field of programmed cell death and apoptosis. It provides a single accessible source of information for both ... See more

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5 years ago

PrePhyloPro: phylogenetic profile-based prediction of whole proteome linkages

Direct and indirect functional links between proteins as well as their interactions as part of larger protein complexes or common signaling pathways may be predicted by analyzing the correlation of ... See more

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7 years ago

Decreased SGK1 Expression and Function Contributes to Behavioral Deficits Induced by Traumatic...

Activity of the protein kinase SGK1 is reduced in the prefrontal cortex of individuals with post-traumatic stress disorder (PTSD), and SGK1 inhibition can cause PTSD-related behavioral changes in an animal model. ... See more

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7 years ago

Science Mission

Reduced activity of a brain protein linked to post-traumatic stress disorder

People with post-traumatic stress disorder (PTSD) have reduced activity of the protein serum and glucocorticoid regulated ... See more

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7 years ago

The Mitochondrial Permeability Transition Pore, the c-Subunit of the F1Fo ATP Synthase, Cellular...

Jonas, E. A., Porter, G. A., Beutner, G., Mnatsakanyan, N. and Alavian, K. N. (2015) The Mitochondrial Permeability Transition Pore, the c-Subunit of the F1Fo ATP Synthase, Cellular Development, and ... See more

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7 years ago

Cell death disguised: The mitochondrial permeability transition pore as the c-subunit of the...

http://www.sciencedirect.com/science/article/pii/S104366181500081X

Ion transport across the mitochondrial inner and outer membranes is central to mitochondrial function, including regulation of oxidative phosphorylation and cell death. Although essential for ATP ... See more

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