Kambiz Alavian

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.KNA-01

Kambiz Alavian Ph.D.

Division of Brain Sciences ■ Department of Medicine ■ Imperial College, LondonHammersmith Hospital ■ DuCane Road ■ London ■ W12 0NN ■ UK

Tel: 020 7594 7006 ■ Email: k.alavian@imperial.ac.ukhttp://alavianlab.org/

 

Career and postdoctoral appointments                                        

Lecturer (Tenured), Imperial College London,

Department of Medicine, Division of Brain Sciences, London, UK

  08/2013 – present

Assistant Professor (Adjunct), Yale University, School of Medicine,

Department of Internal Medicine, Endocrinology, New Haven, CT

  08/2013 – present

Associate Research Scientist, Yale University, School of Medicine,

Department of Internal Medicine, Endocrinology, New Haven, CT.

  2010 – 2013

Postdoctoral Associate, Neuroscience, Yale University,

School of Medicine, New Haven, CT

  2008 – 2010

Postdoctoral Fellow, Neuroscience, Harvard Medical School,

Belmont, MA.

  2006 – 2008

 

Education/training                                                                                                                              

Ph.D., Neuroscience, University of Heidelberg, Germany   2003-2006
Master of Science, Biology, Illinois Institute of Technology, Chicago, IL.   2002-2003
Bachelor of Science, Biology, University of Illinois at Chicago, IL.   1998-2001

 

Awards and Honors

Whitman Center Research Award, Marine Biological Laboratory   2017-2018
Fellowship of the Higher Education Academy (FHEA)   2016
Young Bioenergeticist Award, Biophysical Society   2012
NIH/Harvard Medical School Molecular Biology of Neurodegeneration Fellowship   2007-2008
AAAS/Science Program for Excellence in Science   2007-2008
Dean’s Scholarship, Illinois Institute of Technology   2002-2003
Member of Honors College, University of Illinois at Chicago   1999-2001
Member of Phi Theta Kappa International Honor Society   1998-1999

 

Peer Reviewed Publications

  1. Park HA, Licznerski P, Mnatsakanyan N, Niu Y, Sacchetti S, Wu J, Polster BM, Alavian KN, Jonas EA: Inhibition of Bcl-xL prevents pro-death actions of DeltaN-Bcl-xL at the mitochondrial inner membrane during glutamate excitotoxicity. Cell Death Differ 2017.10.1038/cdd.2017.123
  2. Niu Y, Moghimyfiroozabad S, Safaie S, Yang Y, Jonas EA, Alavian KN: Phylogenetic Profiling of Mitochondrial Proteins and Integration Analysis of Bacterial Transcription Units Suggest Evolution of F1Fo ATP Synthase from Multiple Modules. Journal of Molecular Evolution 2017.10.1007/s00239-017-9819-3
  3. Niu Y, Liu C, Moghimyfiroozabad S, Yang Y, Alavian KN: PrePhyloPro: phylogenetic profile-based prediction of whole proteome linkages. PeerJ 2017, 5:e3712.10.7717/peerj.3712
  4. Jonas EA, Porter GA, Beutner G, Mnatsakanyan N, Park HA, Mehta N, Chen R, Alavian KN: The mitochondrial permeability transition pore: molecular structure and function in health and disease. In Molecular Basis for Mitochondrial Signaling. Springer Series in Biological and Medical Physics, Biomedical Engineering: Springer; 2017
  5. Beutner G, Alavian KN, Jonas EA, Porter GA, Jr.: The Mitochondrial Permeability Transition Pore and ATP Synthase. Handb Exp Pharmacol 2017, 240:21-46.10.1007/164_2016_5
  6. Mnatsakanyan N, Beutner G, Porter GA, Alavian KN, Jonas EA: Physiological roles of the mitochondrial permeability transition pore. J Bioenerg Biomembr 2016.10.1007/s10863-016-9652-1
  7. Jonas EA, Porter GA, Beutner G, Mnatsakanyan N, Alavian KN: The Mitochondrial Permeability Transition Pore, the c-Subunit of the F1Fo ATP Synthase, Cellular Development, and Synaptic Efficiency. In The Functions, Disease-Related Dysfunctions, and Therapeutic Targeting of Neuronal Mitochondria. John Wiley & Sons, Inc; 2016: 31-6410.1002/9781119017127.ch2
  8. Jonas EA, Miranda P, Gribkoff V, Alavian KN, Park H-A, Wu J, Chavez A, Zukin RS, Hardwick JM, Mnatsakanyan N: PTP and LTP: The physiological role of the permeability transition pore in learning and memory. Biochimica et Biophysica Acta (BBA)-Bioenergetics 2016, 1857:e66-e67
  9. Weinert M, Selvakumar T, Tierney TS, Alavian KN: Isolation, culture and long-term maintenance of primary mesencephalic dopaminergic neurons from embryonic rodent brains. J Vis Exp 2015.10.3791/52475
  10. Selvakumar T, Alavian KN, Tierney T: Analysis of Gene Expression Changes in the Rat Hippocampus After Deep Brain Stimulation of the Anterior Thalamic Nucleus. J Vis Exp 2015:e52457.doi:10.3791/52457
  11. Park HA, Licznerski P, Alavian KN, Shanabrough M, Jonas EA: Bcl-xL is necessary for neurite outgrowth in hippocampal neurons. Antioxid Redox Signal 2015, 22:93-108.10.1089/ars.2013.5570
  12. Licznerski P, Duric V, Banasr M, Alavian KN, Ota KT, Kang HJ, Jonas EA, Ursano R, Krystal JH, Duman RS, Traumatic Stress Brain Study G: Decreased SGK1 Expression and Function Contributes to Behavioral Deficits Induced by Traumatic Stress. PLoS Biol 2015, 13:e1002282.10.1371/journal.pbio.1002282
  13. Jonas EA, Porter GA, Jr., Beutner G, Mnatsakanyan N, Alavian KN: Cell death disguised: The mitochondrial permeability transition pore as the c-subunit of the FF ATP synthase. Pharmacol Res 2015.10.1016/j.phrs.2015.04.013
  14. Cotroneo E, Ashek A, Wang L, Wharton J, Dubois OD, Bozorgi SS, Busbridge M, Alavian KN, Wilkins MR, Zhao L: Iron Homeostasis and Pulmonary Hypertension: Iron Deficiency Leads to Pulmonary Vascular Remodeling in the Rat. Circ Res 2015.10.1161/CIRCRESAHA.116.305265
  15. Alavian KN, Dworetzky SI, Bonanni L, Zhang P, Sacchetti S, Li H, Signore AP, Smith PJ, Gribkoff VK, Jonas EA: The mitochondrial complex V-associated large-conductance inner membrane current is regulated by cyclosporine and dexpramipexole. Mol Pharmacol 2015, 87:1-8.10.1124/mol.114.095661
  16. Jonas EA, Porter GA, Alavian KN: Bcl-xL in neuroprotection and plasticity. Front Physiol 2014, 5:355.10.3389/fphys.2014.00355
  17. Alavian KN, Jeddi S, Naghipour SI, Nabili P, Licznerski P, Tierney TS: The lifelong maintenance of mesencephalic dopaminergic neurons by Nurr1 and engrailed. J Biomed Sci 2014, 21:27.10.1186/1423-0127-21-27
  18. Alavian KN, Beutner G, Lazrove E, Sacchetti S, Park HA, Licznerski P, Li H, Nabili P, Hockensmith K, Graham M, Porter GA, Jr., Jonas EA: An uncoupling channel within the c-subunit ring of the F1FO ATP synthase is the mitochondrial permeability transition pore. PNAS 2014, 111:10580-10585.10.1073/pnas.1401591111
  19. Sacchetti S, Alavian KN, Lazrove E, Jonas EA: F1FO ATPase vesicle preparation and technique for performing patch clamp recordings of submitochondrial vesicle membranes. J Vis Exp 2013:e4394.10.3791/4394
  20. Li H, Alavian KN, Lazrove E, Mehta N, Jones A, Zhang P, Licznerski P, Graham M, Uo T, Guo J, Rahner C, Duman RS, Morrison RS, Jonas EA: A Bcl-xL-Drp1 complex regulates synaptic vesicle membrane dynamics during endocytosis. Nature Cell Biology 2013, 15:773-785.10.1038/ncb2791
  21. Ofengeim D, Chen YB, Miyawaki T, Li H, Sacchetti S, Flannery RJ, Alavian KN, Pontarelli F, Roelofs BA, Hickman JA, Hardwick JM, Zukin RS, Jonas EA: N-terminally cleaved Bcl-xL mediates ischemia-induced neuronal death. Nature Neurosci 2012, 15:574-580.10.1038/nn.3054
  22. Gray JP, Alavian KN, Jonas EA, Heart EA: NAD kinase regulates the size of the NADPH pool and insulin secretion in pancreatic beta-cells. Am J Physiol Endocrinol Metab 2012, 303:E191-199.10.1152/ajpendo.00465.2011
  23. Alavian KN, Dworetzky SI, Bonanni L, Zhang P, Sacchetti S, Mariggio MA, Onofrj M, Thomas A, Li H, Mangold JE, Signore AP, Demarco U, Demady DR, Nabili P, Lazrove E, Smith PJ, Gribkoff VK, Jonas EA: Effects of dexpramipexole on brain mitochondrial conductances and cellular bioenergetic efficiency. Brain Res 2012, 1446:1-11.10.1016/j.brainres.2012.01.046
  24. Sanchez CE, Tierney TS, Gale JT, Alavian KN, Sahin A, Lee JS, Mulligan RC, Carter BS: Recombinant adeno-associated virus type 2 pseudotypes: comparing safety, specificity, and transduction efficiency in the primate striatum. Laboratory investigation. J Neurosurg 2011, 114:672-680.10.3171/2010.8.JNS091583
  25. Chen YB, Aon MA, Hsu YT, Soane L, Teng X, McCaffery JM, Cheng WC, Qi B, Li H, Alavian KN, Dayhoff-Brannigan M, Zou S, Pineda FJ, O’Rourke B, Ko YH, Pedersen PL, Kaczmarek LK, Jonas EA, Hardwick JM: Bcl-xL regulates mitochondrial energetics by stabilizing the inner membrane potential. J Cell Biol 2011, 195:263-276.10.1083/jcb.201108059
  26. Alavian KN, Li H, Collis L, Bonanni L, Zeng L, Sacchetti S, Lazrove E, Nabili P, Flaherty B, Graham M, Chen Y, Messerli SM, Mariggio MA, Rahner C, McNay E, Shore GC, Smith PJ, Hardwick JM, Jonas EA: Bcl-xL regulates metabolic efficiency of neurons through interaction with the mitochondrial F1FO ATP synthase. Nat Cell Biol 2011, 13:1224-1233.10.1038/ncb2330
  27. Vahedi S, Rajabian M, Misaghian A, Grbec D, Simon HH, Alavian KN: Parkinson’s disease candidate gene prioritization based on expression profile of midbrain dopaminergic neurons. J Biomed Sci 2010, 17:66.10.1186/1423-0127-17-66
  28. Chung CY, Licznerski P, Alavian KN, Simeone A, Lin Z, Martin E, Vance J, Isacson O: The transcription factor orthodenticle homeobox 2 influences axonal projections and vulnerability of midbrain dopaminergic neurons. Brain 2010, 133:2022-2031.10.1093/brain/awq142
  29. Simon HH, Alavian KN: Transcriptional regulation of their survival: the Engrailed homeobox genes. Adv Exp Med Biol 2009, 651:66-72
  30. Pruszak J, Ludwig W, Blak A, Alavian K, Isacson O: CD15, CD24, and CD29 define a surface biomarker code for neural lineage differentiation of stem cells. Stem Cells 2009, 27:2928-2940.10.1002/stem.211
  31. Alavian KN, Simon HH: Linkage of cDNA expression profiles of mesencephalic dopaminergic neurons to a genome-wide in situ hybridization database. Mol Neurodegener 2009, 4:6.10.1186/1750-1326-4-6
  32. Alavian KN, Sgado P, Alberi L, Subramaniam S, Simon HH: Elevated P75NTR expression causes death of engrailed-deficient midbrain dopaminergic neurons by Erk1/2 suppression. Neural Dev 2009, 4:11.10.1186/1749-8104-4-11
  33. Alavian KN, Scholz C, Simon HH: Transcriptional regulation of mesencephalic dopaminergic neurons: the full circle of life and death. Mov Disord 2008, 23:319-328.10.1002/mds.21640
  34. Sgado P, Alberi L, Gherbassi D, Galasso SL, Ramakers GM, Alavian KN, Smidt MP, Dyck RH, Simon HH: Slow progressive degeneration of nigral dopaminergic neurons in postnatal Engrailed mutant mice. Proc Natl Acad Sci U S A 2006, 103:15242-15247.10.1073/pnas.0602116103
  35. Thuret S, Alavian KN, Gassmann M, Lloyd CK, Smits SM, Smidt MP, Klein R, Dyck RH, Simon HH: The neuregulin receptor, ErbB4, is not required for normal development and adult maintenance of the substantia nigra pars compacta. J Neurochem 2004, 91:1302-1311.10.1111/j.1471-4159.2004.02809.x

 

Patent

Gribkoff, V.K., Dworetzky, S.I., Alavian, K.N. and Jonas, E.A. (2011) Compounds and Methods of Modulating Mitochondrial Bioenergetic Efficiency through an interaction with ATP Synthase (Complex V) and its Subunits. US. Application No. 61/348,698.

 

Journal Services – Editorial Board Member

2016-present              Matters (Science Matters)                                          Editorial Borad Member

2014-present              Biomedicine and Biotechnology                               Editorial Board Member

2013-present              Scientific Reports                                                         Editorial Board Member

2013-present              Frontiers in Bioscience                                               Managing Editor

2013-present              Frontiers in Clinical Medicine                                   Editorial Board Member

2012-present              Cell Biology                                                                    Editorial Board Member

2012-present              Advances in Parkinson’s Disease (APS)                  Editorial Board Member

 

Journal services – independent referee

Science

European Journal of Neuroscience

Nature Protocols

Scientific Reports (Nature Publishing)

The FASEB Journal

Journal of Neurochemistry

Stem Cells

Neuroscience

Therapeutics and Clinical Risk Management

Brain Researh

Frontiers in Clinical Medicine

Febbs Letter

 

Ad hoc grant reviewer

BBSRC

MRC

Cure Parkinson’s Trust

 

Teaching (-related) experience

2015 –              Module leader and lecturer: Cellular and Molecular Neuroscience Module, MSc in Translational Neuroscience course. Developed the module and gave lectures on various cellular and molecular topics, including cytoskeleton, neurodegeneration (Alzheimer’s disease, Parkinson’s disease, Huntington’s disease and ALS), mitochondrial biology, ion channel physiology. Developed a virtual research project aimed at introducing the students to graduate level scientific thinking, hypothesis-driven research, project development and presentation.  Total lecture time: 28 hours. Imperial College London.

2015 –              Course development committee member: MSc in Translational Neuroscience. Curriculum and content development as well as course management for the new master’s program in the Division of Brain Sciences. The program was offered in October 2016. Imperial College London.

2015 –              Lecturer: Parkinson’s disease. Neurodegenerative mechanisms. Imperial College, BSc Neuroscience & Mental Health; Imperial College London.

 

Teaching qualifications and courses

  • PG Certificate (PGCert) in University Learning and Teaching (2015 – 2016)

Modules:

  • Assessment and Feedback
    • Digital learning
    • Public Engagement
    • Research and Teaching
    • Theories of Teaching
    • Introduction to Teaching for Learning
  • Introduction to Supervising PhD Students at Imperial (June 2014)
  • Introduction to Personal Tutoring at Imperial (June 2014)

 

Present and past memberships

2013 – present            Biochemical Society

2009 – present            Biophysical Society (BPS)

2004 – present            New York Academy of Sciences

2005 – present            Society for Neuroscience (SFN)

2008 – 2009                Harvard NeuroDiscovery Center

2007 – 2009                Harvard Stem Cell Institute (HSCI)

2005 – 2006                German Society for Cell Biology (DGZ)

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