Publications

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– Chen R, Park H, Mnatsakanya N, Niu Y, Licznerski P, Wu J, Miranda P, Graham G, Tang J, Boon AJW, Cossu G, Mandemakers W, Bonifati V, Smith PJA, Alavian KN and Jonas EA: Familial Parkinson’s disease protein DJ-1 alters the stoichiometry of ATP synthase components to affect mitochondrial efficiency, protein synthesis and neuronal growth. Accepted, Cell Death and Disease.

– Weinert M, Millet A, Jonas EA, Alavian KN: The mitochondrial metabolic function of DJ-1 is modulated by 14-3-3beta. FASEB J 2019:fj201802754R.

– Mallach A, Weinert M, Arthur J, Gveric D, Tierney TS, Alavian KN: Post mortem examination of Parkinson’s disease brains suggests decline in mitochondrial biomass, reversed by deep brain stimulation of subthalamic nucleus. FASEB J 2019:fj201802628R

– Park HA, Licznerski P, Mnatsakanyan N, Niu Y, Sacchetti S, Wu J, Polster BM, Alavian KN, Jonas EA: Inhibition of Bcl-xL prevents pro-death actions of DeltaN-Bcl-xL at the mitochondrial inner membrane during glutamate excitotoxicity. Cell Death Differ 2017.10.1038/cdd.2017.123

– Niu Y, Moghimyfiroozabad S, Safaie S, Yang Y, Jonas EA, Alavian KN: Phylogenetic Profiling of Mitochondrial Proteins and Integration Analysis of Bacterial Transcription Units Suggest Evolution of F1Fo ATP Synthase from Multiple Modules. Journal of Molecular Evolution 2017.10.1007/s00239-017-9819-3

– Niu Y, Liu C, Moghimyfiroozabad S, Yang Y, Alavian KN: PrePhyloPro: phylogenetic profile-based prediction of whole proteome linkages. PeerJ 2017, 5:e3712.10.7717/peerj.3712

– Jonas EA, Porter GA, Beutner G, Mnatsakanyan N, Park HA, Mehta N, Chen R, Alavian KN: The mitochondrial permeability transition pore: molecular structure and function in health and disease. In Molecular Basis for Mitochondrial Signaling. Springer Series in Biological and Medical Physics, Biomedical Engineering: Springer; 2017

– Beutner G, Alavian KN, Jonas EA, Porter GA, Jr.: The Mitochondrial Permeability Transition Pore and ATP Synthase. Handb Exp Pharmacol 2017, 240:21-46.10.1007/164_2016_5

– Mnatsakanyan N, Beutner G, Porter GA, Alavian KN, Jonas EA: Physiological roles of the mitochondrial permeability transition pore. J Bioenerg Biomembr 2016.10.1007/s10863-016-9652-1

– Jonas EA, Porter GA, Beutner G, Mnatsakanyan N, Alavian KN: The Mitochondrial Permeability Transition Pore, the c-Subunit of the F1Fo ATP Synthase, Cellular Development, and Synaptic Efficiency. In The Functions, Disease-Related Dysfunctions, and Therapeutic Targeting of Neuronal Mitochondria. John Wiley & Sons, Inc; 2016: 31-6410.1002/9781119017127.ch2

– Jonas EA, Miranda P, Gribkoff V, Alavian KN, Park H-A, Wu J, Chavez A, Zukin RS, Hardwick JM, Mnatsakanyan N: PTP and LTP: The physiological role of the permeability transition pore in learning and memory. Biochimica et Biophysica Acta (BBA)-Bioenergetics 2016, 1857:e66-e67

– Jonas EA, Porter GA, Beutner G, Mnatsakanyan N, Alavian KN: The Mitochondrial Permeability Transition Pore, the c-Subunit of the F1Fo ATP Synthase, Cellular Development, and Synaptic Efficiency. In The Functions, Disease-Related Dysfunctions, and Therapeutic Targeting of Neuronal Mitochondria. John Wiley & Sons, Inc; 2015: 31-64

– Licznerski P, Duric V, Banasr M, Alavian KN, Ota KT, Kang HJ, Jonas EA, Ursano R, Krystal JH, Duman RS, Traumatic Stress Brain Study G: Decreased SGK1 Expression and Function Contributes to Behavioral Deficits Induced by Traumatic Stress. PLoS Biol 2015, 13:e1002282. 

– Jonas EA, Porter GA, Jr., Beutner G, Mnatsakanyan N, Alavian KN (2015) Cell death disguised: The mitochondrial permeability transition pore as the c-subunit of the F1Fo ATP synthase. Pharmacol Res. doi:10.1016/j.phrs.2015.04.013

– Alavian KN, Dworetzky SI, Bonanni L, Zhang P, Sacchetti S, Li H, Signore AP, Smith PJ, Gribkoff VK, Jonas EA (2015) The mitochondrial complex V-associated large-conductance inner membrane current is regulated by cyclosporine and dexpramipexole. Molecular pharmacology 87 (1):1-8. doi:10.1124/mol.114.095661

– Cotroneo E, Ashek A, Wang L, Wharton J, Dubois OD, Bozorgi SS, Busbridge M, Alavian KN, Wilkins MR, Zhao L (2015) Iron Homeostasis and Pulmonary Hypertension: Iron Deficiency Leads to Pulmonary Vascular Remodeling in the Rat. Circ Res. doi:10.1161/CIRCRESAHA.116.305265

– Park HA, Licznerski P, Alavian KN, Shanabrough M, Jonas EA (2015) Bcl-xL is necessary for neurite outgrowth in hippocampal neurons. Antioxid Redox Signal 22 (2):93-108. doi:10.1089/ars.2013.5570

– Selvakumar T, Alavian KN, Tierney T (2015) Analysis of Gene Expression Changes in the Rat Hippocampus After Deep Brain Stimulation of the Anterior Thalamic Nucleus. (97):e52457. doi:doi:10.3791/52457

– Weinert M, Selvakumar T, Tierney TS, Alavian KN (2015) Isolation, culture and long-term maintenance of primary mesencephalic dopaminergic neurons from embryonic rodent brains. Journal of visualized experiments : JoVE (96). doi:10.3791/52475

– Jonas, E.A., Porter, G.A., and Alavian, K.N. (2014). Bcl-xL in neuroprotection and plasticity. Frontiers in physiology 5, 355.

– Alavian, K.N., Jeddi, S., Naghipour, S.I., Nabili, P., Licznerski, P., and Tierney, T.S. (2014). The lifelong maintenance of mesencephalic dopaminergic neurons by Nurr1 and engrailed. J Biomed Sci 21, 27.

– Alavian, K.N., Beutner, G., Lazrove, E., Sacchetti, S., Park, H.A., Licznerski, P., Li, H., Nabili, P., Hockensmith, K., Graham, M., et al. (2014). An uncoupling channel within the c-subunit ring of the F1FO ATP synthase is the mitochondrial permeability transition pore. Proc Natl Acad Sci U S A 111, 10580-10585.

– Sacchetti, S., Alavian, K.N., Lazrove, E., and Jonas, E.A. (2013). F1FO ATPase Vesicle Preparation and Technique for Performing Patch Clamp Recordings of Submitochondrial Vesicle Membranes. JoVE.

– Li, H., Alavian, K.N., Lazrove, E., Mehta, N., Jones, A., Zhang, P., Licznerski, P., Graham, M., Uo, T., Guo, J., et al. (2013). A Bcl-xL-Drp1 complex regulates synaptic vesicle membrane dynamics during endocytosis. Nature Cell Biology 15, 773-785.

– Ofengeim, D., Chen, Y.B., Miyawaki, T., Li, H., Sacchetti, S., Flannery, R.J., Alavian, K.N., Pontarelli, F., Roelofs, B.A., Hickman, J.A., et al. (2012). N-terminally cleaved Bcl-xL mediates ischemia-induced neuronal death. Nature Neuroscience 15, 574-580.

– Gray, J.P., Alavian, K.N., Jonas, E.A., and Heart, E.A. (2012). NAD kinase (NADK) regulates the size of NADPH pool and insulin secretion in pancreatic beta cells. Am J Physiol Endocrinol Metab.

– Alavian, K.N., Dworetzky, S.I., Bonanni, L., Zhang, P., Sacchetti, S., Mariggio, M.A., Onofrj, M., Thomas, A., Li, H., Mangold, J.E., et al. (2012). Effects of dexpramipexole on brain mitochondrial conductances and cellular bioenergetic efficiency. Brain Res 1446, 1-11.

– Sanchez, C.E., Tierney, T.S., Gale, J.T., Alavian, K.N., Sahin, A., Lee, J.S., Mulligan, R.C., and Carter, B.S. (2011). Recombinant adeno-associated virus type 2 pseudotypes: comparing safety, specificity, and transduction efficiency in the primate striatum. Laboratory investigation. J Neurosurg 114, 672-680.

– Gribkoff, V., Dworetzky, S., Jonas, E., and Alavian, K. (2011). Compounds and methods of modulating mitochondrial bioenergetic efficiency through an interaction with ATP synthase (complex V) and its subunits (WO Patent 2,011,150,221).

– Chen, Y.B., Aon, M.A., Hsu, Y.T., Soane, L., Teng, X., McCaffery, J.M., Cheng, W.C., Qi, B., Li, H., Alavian, K.N., et al. (2011). Bcl-xL regulates mitochondrial energetics by stabilizing the inner membrane potential. Journal of Cell Biology 195, 263-276.

– Alavian, K.N., Li, H., Collis, L., Bonanni, L., Zeng, L., Sacchetti, S., Lazrove, E., Nabili, P., Flaherty, B., Graham, M., et al. (2011). Bcl-xL regulates metabolic efficiency of neurons through interaction with the mitochondrial F1FO ATP synthase. Nature Cell Biology 13, 1224-1233.

– Vahedi, S., Rajabian, M., Misaghian, A., Grbec, D., Simon, H.H., and Alavian, K.N. (2010). Parkinson’s disease candidate gene prioritization based on expression profile of midbrain dopaminergic neurons. J Biomed Sci 17, 66.

– Chung, C.Y., Licznerski, P., Alavian, K.N., Simeone, A., Lin, Z., Martin, E., Vance, J., and Isacson, O. (2010). The transcription factor orthodenticle homeobox 2 influences axonal projections and vulnerability of midbrain dopaminergic neurons. Brain 133, 2022-2031.

– Simon, H.H., and Alavian, K.N. (2009). Transcriptional regulation of their survival: the Engrailed homeobox genes. Adv Exp Med Biol 651, 66-72.

– Pruszak, J., Ludwig, W., Blak, A., Alavian, K., and Isacson, O. (2009). CD15, CD24, and CD29 define a surface biomarker code for neural lineage differentiation of stem cells. Stem Cells 27, 2928-2940.

– Alavian, K.N., and Simon, H.H. (2009). Linkage of cDNA expression profiles of mesencephalic dopaminergic neurons to a genome-wide in situ hybridization database. Mol Neurodegener 4, 6.

– Alavian, K.N., Sgado, P., Alberi, L., Subramaniam, S., and Simon, H.H. (2009). Elevated P75NTR expression causes death of engrailed-deficient midbrain dopaminergic neurons by Erk1/2 suppression. Neural Dev 4, 11.

– Alavian, K.N., Scholz, C., and Simon, H.H. (2008). Transcriptional regulation of mesencephalic dopaminergic neurons: the full circle of life and death. Mov Disord 23, 319-328.

– Sgado, P., Alberi, L., Gherbassi, D., Galasso, S.L., Ramakers, G.M., Alavian, K.N., Smidt, M.P., Dyck, R.H., and Simon, H.H. (2006). Slow progressive degeneration of nigral dopaminergic neurons in postnatal Engrailed mutant mice. PNAS 103, 15242-15247.

– Thuret, S., Alavian, K.N., Gassmann, M., Lloyd, C.K., Smits, S.M., Smidt, M.P., Klein, R., Dyck, R.H., and Simon, H.H. (2004). The neuregulin receptor, ErbB4, is not required for normal development and adult maintenance of the substantia nigra pars compacta. J Neurochem 91, 1302-1311.

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